Blar i forfatter "Fredheim, Elizabeth G. Aarag"

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    • The chemotherapeutic drug methotrexate selects for antibiotic resistance 

      Gudmundsdottir, Jonina; Fredheim, Elizabeth G. Aarag; Koumans, Catharina I.M.; Hegstad, Joachim; Tang, Po-Cheng; Andersson, Dan I.; Samuelsen, Ørjan; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-11)
      Background: Understanding drivers of antibiotic resistance evolution is fundamental for designing optimal treatment strategies and interventions to reduce the spread of antibiotic resistance. Various cytotoxic drugs used in cancer chemotherapy have antibacterial properties, but how bacterial populations are affected by these selective pressures is unknown. Here we test the hypothesis that the widely ...

    • Dominance between plasmids determines the extent of biofilm formation 

      Gama, João Alves; Fredheim, Elizabeth G. Aarag; Cléon, Francois Pierre Alexandre; Reis, Ana Maria; Zilhão, Rita; Dionisio, Francisco (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-26)
      Bacterial biofilms have an impact in medical and industrial environments because they often confer protection to bacteria against harmful agents, and constitute a source from which microorganisms can disperse. Conjugative plasmids can enhance bacterial ability to form biofilms because conjugative pili act as adhesion factors. However, plasmids may interact with each other, either facilitating or ...

    • Identification of surface proteins in a clinical Staphylococcus haemolyticus isolate by bacterial surface shaving 

      Wolden, Runa; Pain, Maria; Karlsson, Roger; Karlsson, Anders; Fredheim, Elizabeth G. Aarag; Cavanagh, Jorunn Pauline (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-07)
      <p><i>Background - </i>The skin commensal <i>Staphylococcus haemolyticus</i> is an emerging nosocomial pathogen. Despite its clinical relevance, published information about <i>S. haemolyticus</i> virulence factors is scarce. In this study, the adhesive and biofilm forming properties of ten clinical and ten commensal <i>S. haemolyticus</i> strains were examined using standard adhesion and biofilm ...

    • Liposomal delivery of antibiotic loaded nucleic acid nanogels with enhanced drug loading and synergistic anti-inflammatory activity against S. aureus intracellular infections 

      Obuobi, Sybil Akua Okyerewa; Julin, Kjersti; Fredheim, Elizabeth G. Aarag; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-07)
      The persistence of <i>Staphylococcus aureus</i> has been accredited to its ability to escape immune response via host cell invasion. Despite the efficacy of many antibiotics against <i>S. aureus</i>, the high extracellular concentrations of conventional antibiotics required for bactericidal activity is limited by their low cellular accumulation and poor intracellular retention. While nanocarriers ...

    • Synthesis and Antimicrobial Activity of Short Analogues of the Marine Antimicrobial Peptide Turgencin A: Effects of SAR Optimizations, Cys-Cys Cyclization and Lipopeptide Modifications 

      Dey, Hymonti; Simonovic, Danijela; Hagen, Ingrid Sofie Norberg-Schulz; Vasskog, Terje; Fredheim, Elizabeth G. Aarag; Blencke, Hans-Matti; Anderssen, Trude; Strøm, Morten B.; Haug, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-10)
      We have synthesised short analogues of the marine antimicrobial peptide Turgencin A from the colonial Arctic ascidian Synoicum turgens. In this study, we focused on a central, cationic 12-residue Cys-Cys loop region within the sequence. Modified (tryptophan- and arginine-enriched) linear peptides were compared with Cys-Cys cyclic derivatives, and both linear and Cys-cyclic peptides were N-terminally ...